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IV Nutrition

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IV Vitamin C Nutrition

Dental surgical procedure often promote inflammation in teeth and associated bone. Cleaning out cavities, deep pockets of calcified plaque, or infected teeth are all associated with trauma induced inflammation, pain, and bacterial mobilization. Vitamin C can counteract these traumas by performing major roles in reducing inflammation and improving immune function.  Vitamin C is a vital component of your body’s healing process.

General Benefits of Vitamin C

Did you know that our bodies cannot make vitamin C? Therefore, we must obtain it from specific nutrients in our diet or supplements. Often, Vitamin C works in concert with our enzymes to carry out different tasks throughout the body.

Vitamin C is active in the adrenal glands, to guard against fatigue1, and protects your soft tissues2. Vitamin C is necessary for collagen production3, which impacts hair, skin, and nail formation and maintenance. Vitamin C helps reduce damage to the heart and regulates how your body’s stress hormones impact your vasculature4.

It has also been shown to help strengthen the density of your bones5 and increase the production and function of white blood cells to optimize immune function6. Vitamin C has shown benefits in helping the body find and turn over cancer cells7.

Dental Health Specific Benefits of High Dose IV Vitamin C

IV Vitamin C nutrition ensures that the essential vitamin bypasses your digestive tract and is delivered directly to your peripheral tissues, like those of the mouth. This allows any traumatized oral structures to absorb more of the vitamin, which increases the benefit from its properties much more quickly and efficiently. The following are specific properties of Vitamin C that augment the experiences and outcomes of dental work:

Acute Pain Reduction

In patients undergoing painful dental procedures, or those that have a low pain tolerance, IV vitamin C has been shown to have a significant analgesic effect within the first 24 hours after administration8,9.

Reduction in Inflammation

Swelling, especially inside the confined space of a tooth is an undesirable effect after dental work. IV vitamin C reduces oxidative stress-induced inflammation2,10, which is specifically beneficial inside the vasculature of the teeth that were worked on. Vitamin C also decreases histamine levels and generally reduces the body’s inflammatory signaling molecules (cytokines)11.

Improved Immune Function

Instead of antibiotics, vitamin C can help bolster your bodies immune defense after surgery. Vitamin C improves epithelial barriers, the function of white blood cells, and the rate at which they are produced6.

Greater Healing Capacity

Vitamin C plays a critical role in both bony and soft tissue repair. After dental surgery like tooth extraction or soft tissue trauma, a surplus of Vitamin C in the tissues would be of benefit to healing.

Risks of IV Vitamin C

IV high-dose vitamin C has shown very few side effects in clinical studies. However, there are a few patient populations where this level of nutrition carries certain risks.

  • If you have a history of kidney disease or kidney failure, you should not receive high dose vitamin C. Additionally, if you have a recurrent history of kidney stones, you should not be treated with high-dose vitamin C7.
  • If you have an inherited metabolic disorder called G6PD, high dose vitamin C can cause temporary fatigue and should be avoided7.
  1. Suh SY, Bae WK, Ahn HY, Choi SE, Jung GC, Yeom CH. Intravenous vitamin C administration reduces fatigue in office workers: a double-blind randomized controlled trial. Nutr J. 2012;11:7. Published 2012 Jan 20. doi:10.1186/1475-2891-11-7

link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273429/

  1. Aschauer S, Gouya G, Klickovic U, et al. Effect of systemic high dose vitamin C therapy on forearm blood flow reactivity during endotoxemia in healthy human subjects. Vascul Pharmacol. 2014;61(1):25-29. doi:10.1016/j.vph.2014.01.007

link: https://pubmed.ncbi.nlm.nih.gov/27219124/

  1. Gref, R., Deloménie, C., Maksimenko, A. et al.Vitamin C–squalene bioconjugate promotes epidermal thickening and collagen production in human skin. Sci Rep10, 16883 (2020). https://doi.org/10.1038/s41598-020-72704-1

link: https://www.nature.com/articles/s41598-020-72704-1

  1. Plotnick MD, D’Urzo KA, Gurd BJ, Pyke KE. The influence of vitamin C on the interaction between acute mental stress and endothelial function. Eur J Appl Physiol. 2017;117(8):1657-1668. doi:10.1007/s00421-017-3655-4

link: https://pubmed.ncbi.nlm.nih.gov/28612123/

  1. Aghajanian P, Hall S, Wongworawat MD, Mohan S. The Roles and Mechanisms of Actions of Vitamin C in Bone: New Developments. J Bone Miner Res. 2015;30(11):1945-1955. doi:10.1002/jbmr.2709

link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833003/

  1. Carr AC, Maggini S. Vitamin C and Immune Function. Nutrients. 2017;9(11):1211. Published 2017 Nov 3. doi:10.3390/nu9111211

link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707683/

  1. NIH National Cancer Institute Protocol for High Dose Vitamin C. https://www.cancer.gov/about-cancer/treatment/cam/patient/vitamin-c-pdq
  2. Ayatollahi V, Dehghanpour Farashah S, Behdad S, Vaziribozorg S, Rabbani Anari M. Effect of intravenous vitamin C on postoperative pain in uvulopalatopharyngoplasty with tonsillectomy. Clin Otolaryngol. 2017 Feb;42(1):139-143. doi: 10.1111/coa.12684. Epub 2016 Jun 7. PMID: 27219124.

link: https://pubmed.ncbi.nlm.nih.gov/27219124/

  1. Jacques H, Jérôme V, Antoine C, et al. Prospective randomized study of the vitamin C effect on pain and complex pain regional syndrome after total knee arthroplasty [published correction appears in Int Orthop. 2021 Feb 22;:]. Int Orthop. 2021;45(5):1155-1162. doi:10.1007/s00264-020-04936-9

link: https://pubmed.ncbi.nlm.nih.gov/33438072/

  1. Chen Y., Luo G., Yuan J., Wang Y., Yang X., Wang X., Li G., Liu Z., Zhong N. Vitamin C mitigates oxidative stress and tumor necrosis factor-alpha in severe community-acquired pneumonia and LPS-induced macrophages. Mediators Inflamm. 2014;2014:426740. doi: 10.1155/2014/426740.

link: https://pubmed.ncbi.nlm.nih.gov/25253919/


  1. Molina N., Morandi A.C., Bolin A.P., Otton R. Comparative effect of fucoxanthin and vitamin C on oxidative and functional parameters of human lymphocytes. Int. Immunopharmacol. 2014;22:41–50. doi: 10.1016/j.intimp.2014.06.026

link: https://pubmed.ncbi.nlm.nih.gov/24975831/